Effect of epirubicin on H-3-thymidine labelling index in cultured L-strain cells


Ozcan F., Topcul M., Yilmazer N., Ridvanogullari M.

10th Mediterranean Congress of Chemotherapy, Antalya, Turkey, 20 - 25 October 1996, pp.335-339 identifier

  • Publication Type: Conference Paper / Full Text
  • Volume:
  • City: Antalya
  • Country: Turkey
  • Page Numbers: pp.335-339

Abstract

The effect of epirubicin (EPI) on H-3-thymidine labelling index (H-3-TdR LI) of L-strain cells in culture was investigated in our study. EPI concentrations of 0.001 mu g/ml, 0.01 mu g/ml and 0.1 mu g/ml were applied to the cells for a period of time of 4, 8, 16 and 32 hours, followed by a continuous labelling proccess in H-3-TdR medium, which does not contain drug, for 0 to 30 hours. The results obtained show that EPI diminishes labelling index of L-strain cells, depending on time and applied concentrations.