Delayed onset bleomycin-induced pneumonitis
UROLOGY, vol.66, no.1, 2005 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 66 Issue: 1
- Publication Date: 2005
- Doi Number: 10.1016/j.urology.2005.01.038
- Journal Name: UROLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Istanbul University Affiliated: Yes
Abstract
We describe a 39-year-old male patient who developed bleomycin-induced pneumonitis 2 years after completion of chemotherapy for nonseminomatous testicular cancer. Bleomycin sometimes causes fatal pulmonary toxicity, including bleomycin-induced pneumonitis. The central event in the development of pneumonitis is endothelial damage of the lung vasculature due to bleomycin-induced cytokines and free radicals. Pulmonary toxicity usually begins at bleomycin administration. The development of bleomycin-induced pneumonitis up to 6 months after bleomycin therapy has also been reported. We report a patient who developed bleomycin-induced pneumonitis 2 years after the initiation of bleomycin-containing chemotherapy regimens.