We report here a case of a 22-year-old female patient with hemophilia A who had a bimaxillary osteotomy operation. Adequate replacement of Factor VIII and DDAVP(1 deamino-8-D-arginine vazopressin) led to the achievement of hemostasis during and after the surgery. Le Fort I maxillary osteotomy and mandibular sagittal split osteotomies were done to correct the facial profile of this hemophiliac patient with a class III malocclusion and posterior open-bite deformity. Careful preoperative evaluation and close cooperation with the hematologist are required if surgery is to be successful. The operation was uneventful and no postoperative complication was observed.