The Effects of Riluzole on Neurological, Brain Biochemical, and Histological Changes in Early and Late Term of Sepsis in Rats

Toklu H. Z., Uysal M. K., KABASAKAL L., ŞİRVANCI S., ERCAN F., Kaya M.

JOURNAL OF SURGICAL RESEARCH, vol.152, no.2, pp.238-248, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 152 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1016/j.jss.2008.03.013
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.238-248
  • Istanbul University Affiliated: Yes

Abstract

Objective. One of the underlying mechanisms of sepsis is thought to be the oxidative damage due to the generation of free radicals. Glutamate, the major excitatory amino acid in the brain, is known to play an important role in blood brain barrier (BBB) permeability, brain edema, and oxidative damage in pathological conditions. Riluzole, a glutamate release inhibitor, has been shown to have neuroprotective effects in several animal models. The aim of our study was to investigate the putative protective effect of riluzole against sepsis-induced brain injury.