Cytotoxic Sesquiterpene Coumarins from the Roots of Heptaptera cilicica


TOSUN F., Aytar E. C. , Beutler J. A. , Wilson J. A. , Miski M.

RECORDS OF NATURAL PRODUCTS, vol.15, no.6, pp.529-536, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.25135/rnp.242.21.02.1990
  • Title of Journal : RECORDS OF NATURAL PRODUCTS
  • Page Numbers: pp.529-536

Abstract

Preliminary 2-day cancer cell screening assays indicated that the dichloromethane extract of the roots of Heptaptera cilicica showed relatively strong cytotoxic activity. Eleven sesquiterpene coumarin ethers with potent and selective cytotoxic activities were isolated from the dichloromethane extract of the roots of H. cilicica. Furthermore, revised spectroscopic data for 14'-acetoxybadrakemone (4) and complete NMR spectroscopic assignments for colladonin (6) and colladin (7) are reported.