Effects of valsartan on stress-induced changes of serum vascular endothelial growth factor and nitric oxide in mice

Erbas B., Uresin Y., Ozek M., Dogru-Abbasoglu S.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.116, sa.5, ss.601-611, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 116 Sayı: 5
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1080/00207450600592131
  • Dergi Adı: INTERNATIONAL JOURNAL OF NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.601-611
  • Anahtar Kelimeler: angiotensin II, chronic stress, nitric oxide, valsartan, vascular endothelial growth factor, FACTOR GENE-EXPRESSION, SMOOTH-MUSCLE-CELLS, ANGIOTENSIN-II, AMINO-ACIDS, BEHAVIORAL-RESPONSES, RECEPTOR BLOCKADE, RATS, RELEASE, ANGIOGENESIS, SYNTHASE
  • İstanbul Üniversitesi Adresli: Evet

Özet

This study investigated the effects of renin- angiotensin system ( RAS) blockade on stress- induced changes of serum vascular endothelial growth factor ( VEGF) and nitric oxide ( NO) in mice. Chronic stress increased the serum NO levels significantly compared to control group ( p =.0172). Valsartan, an angiotensin II receptor antagonist, alone, did not make significant difference versus control group. In chronic stress + valsartan group, serum NO levels decreased nonsignificantly compared to chronic stress group. There was a nonsignificant increase in serum VEGF levels after chronic stress. Valsartan alone or with chronic stress did not significantly affect the serum VEGF levels. In conclusion, there was no correlation between NO and VEGF changes during the stress response. In this respect, there may be other mechanisms to explain the stress- induced NO increase.