Evaluation of GAD67 immunoreactivity in the region of substantia nigra pars reticulata in resistance to development of convulsive seizure in genetic absence epilepsy rats


Gulcebi M., Akman O., Carcak N. , Karamahmutoglu T., ONAT F.

NORTHERN CLINICS OF ISTANBUL, cilt.3, ss.161-167, 2016 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 3 Konu: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.14744/nci.2016.16056
  • Dergi Adı: NORTHERN CLINICS OF ISTANBUL
  • Sayfa Sayısı: ss.161-167

Özet

OBJECTIVE: Nonconvulsive absence epilepsy and convulsive epilepsy seizures are rarely seen in the same patient. It has been demonstrated that there is a resistance to development of convulsive seizures in genetic absence epilepsy models. The present study investigated glutamic acid decarboxylase (GAD) immunoreactivity in the brain region related to the interaction of these two seizure types, namely substantia nigra pars reticulata (SNR) subregions, SNRantenor and SNRpostenor.