Akademik Veri Yönetim Sistemi
Sustainable Chemistry and Pharmacy, cilt.52, ss.102469-102485, 2026 (Scopus)
Curcumin, the main compound of the turmeric plant, is widely used as a
food supplement. In recent years, it has become one of the popular
nutraceutical compounds with its anti-cancer, anti-inflammatory and
antioxidant properties. However, the effectiveness of curcumin is
limited due to solubility problems in hydrophilic environments. The
contribution of deep eutectic solvents (DES), one of the alternative
solvents with high performance for many applications, to the
bioaccessibility of curcumin was investigated. The best results were
obtained using choline chloride-1,2-propanediol-based (CC:PD) mixtures.
In addition, the stability and application problems of DESs prepared for
high concentration curcumin solutions were solved by modifying them
with 0.25 to 7 mol of cosolvent (water and ethanol) per 1 mol of CC.
Curcumin solutions in solvent systems containing deep eutectic solvents
(DES) and ethanol (EtOH) were encapsulated in alginate-chitosan
hydrogels at 10%, 25% and 50% by mass. In vitro controlled release
behavior of the obtained curcumin-loaded polymeric beads was studied in
simulated gastric fluid (SGF), simulated small intestinal fluid (SIF)
and simulated colon fluid (SCF). The results showed that the cosolvent
composition of 1:2:2 CC-PD-EtOH exhibited an equilibrium curcumin
concentration more than 6 times that of ethanol, the commonly used
solvent of curcumin. Drug release studies showed that the highest
curcumin release of hydrogel beads occurred in SCF medium. In addition,
greenness evaluation using AGREE and AGREEprep metrics confirmed that
the developed system is strongly aligned with green chemistry
principles.