Prenatal diagnosis and outcome of unilateral multicystic kidney

Turkyilmaz G., Cetin B., Erturk E., Sivrikoz T., Kalelioglu I., Has R., ...More

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol.41, no.7, pp.1071-1075, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 7
  • Publication Date: 2021
  • Doi Number: 10.1080/01443615.2020.1845631
  • Journal Name: JOURNAL OF OBSTETRICS AND GYNAECOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1071-1075
  • Keywords: Anomaly, kidney, nephrectomy, prenatal, ultrasonography
  • Istanbul University Affiliated: Yes

Abstract

We reviewed the records of 144 patients. The mean gestational age at first US diagnosis was 27.5 +/- 4.3 weeks. An anomaly of the contralateral kidney was detected in 25% of cases. An extrarenal anomaly was detected in 13.8%. Karyotype analysis was performed in 16.6% of cases and revealed trisomy 18 in 2 cases with extrarenal defects. Karyotype analysis was normal in all the patients who had isolated multicystic dysplastic kidney (MCDK). The diagnostic accuracy of prenatal ultrasound was 92.2%. Contralateral kidney anomaly was detected 33.9% of patients, and half of these were vesicoureteral reflux. Antihypertensive therapy was required in 2.6% of cases. Nephrectomy was performed in 8%, and partial or total involution of MCDK was achieved in 33.9% of patients. MCDK can be accurately diagnosed by prenatal sonography, and prognosis depends on extrarenal and contralateral renal abnormalities. In isolated cases, require of surgery is rare, and serial follow-up is suggested to determine involution. Impact statement