AmpC beta-lactamase in an Escherichia coli clinical isolate confers resistance to expanded-spectrum cephalosporins

Mammeri H., Nazic H., Naas T., Poirel L., Leotard S., Nordmann P.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol.48, no.10, pp.4050-4053, 2004 (SCI-Expanded) identifier identifier identifier


Cloning, sequencing, and biochemical analysis identified a novel AmpC-type beta-lactamase conferring resistance to extended-spectrum cephalosporins in an Escherichia coli clinical isolate. This enzyme, exhibiting 14 amino acid substitutions compared to a reference AmpC cephallosporinase of E. coli, hydrolyzed ceftazidime and cefepime significantly.