AmpC beta-lactamase in an Escherichia coli clinical isolate confers resistance to expanded-spectrum cephalosporins

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Atıf İçin Kopyala

Mammeri H., Nazic H., Naas T., Poirel L., Leotard S., Nordmann P.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, cilt.48, sa.10, ss.4050-4053, 2004 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 48 Sayı: 10
• Basım Tarihi: 2004
• Doi Numarası: 10.1128/aac.48.10.4050-4053.2004
• Dergi Adı: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.4050-4053
• İstanbul Üniversitesi Adresli: Hayır

Özet

Cloning, sequencing, and biochemical analysis identified a novel AmpC-type beta-lactamase conferring resistance to extended-spectrum cephalosporins in an Escherichia coli clinical isolate. This enzyme, exhibiting 14 amino acid substitutions compared to a reference AmpC cephallosporinase of E. coli, hydrolyzed ceftazidime and cefepime significantly.