AmpC beta-lactamase in an Escherichia coli clinical isolate confers resistance to expanded-spectrum cephalosporins

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Mammeri H., Nazic H., Naas T., Poirel L., Leotard S., Nordmann P.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol.48, no.10, pp.4050-4053, 2004 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 48 Issue: 10
• Publication Date: 2004
• Doi Number: 10.1128/aac.48.10.4050-4053.2004
• Journal Name: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.4050-4053
• Istanbul University Affiliated: No

Abstract

Cloning, sequencing, and biochemical analysis identified a novel AmpC-type beta-lactamase conferring resistance to extended-spectrum cephalosporins in an Escherichia coli clinical isolate. This enzyme, exhibiting 14 amino acid substitutions compared to a reference AmpC cephallosporinase of E. coli, hydrolyzed ceftazidime and cefepime significantly.