Effect of harmane on mononeuropathic pain in rats


Aricioglu F., Korcegez E., Ozyalcin S.

AGMATINE AND IMIDAZOLINES: THEIR NOVEL RECEPTORS AND ENZYMES, cilt.1009, ss.180-184, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 1009
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1196/annals.1304.021
  • Dergi Adı: AGMATINE AND IMIDAZOLINES: THEIR NOVEL RECEPTORS AND ENZYMES
  • Sayfa Sayısı: ss.180-184

Özet

This study was designed to investigate the effect of the endogenous beta-carboline, harmane, on neuropathic pain produced by chronic constriction injury (CCI) of the sciatic nerve. Thermal allodynia evaluations were made preoperatively, postoperatively on the fifteenth day, and after harmane administration. Harmane (1, 2.5, 5, 10, or 20 mg/kg) was administered intraperitoneally for 5 days beginning from postoperative day 15. Treatment with harmane had a profound anti-allodynic effect in a dose-dependent manner. In conclusion, harmane might provide a new approach to treatment of neuropathic pain.