Effect of harmane on mononeuropathic pain in rats


Aricioglu F., Korcegez E., Ozyalcin S.

AGMATINE AND IMIDAZOLINES: THEIR NOVEL RECEPTORS AND ENZYMES, vol.1009, pp.180-184, 2003 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 1009
  • Publication Date: 2003
  • Doi Number: 10.1196/annals.1304.021
  • Journal Name: AGMATINE AND IMIDAZOLINES: THEIR NOVEL RECEPTORS AND ENZYMES
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.180-184

Abstract

This study was designed to investigate the effect of the endogenous beta-carboline, harmane, on neuropathic pain produced by chronic constriction injury (CCI) of the sciatic nerve. Thermal allodynia evaluations were made preoperatively, postoperatively on the fifteenth day, and after harmane administration. Harmane (1, 2.5, 5, 10, or 20 mg/kg) was administered intraperitoneally for 5 days beginning from postoperative day 15. Treatment with harmane had a profound anti-allodynic effect in a dose-dependent manner. In conclusion, harmane might provide a new approach to treatment of neuropathic pain.