Akademik Veri Yönetim Sistemi
JOURNAL OF PHARMACEUTICAL NEGATIVE RESULTS, cilt.13, sa.10, ss.6642-6649, 2023 (ESCI)
It is unknown how the urine microbiome of young, healthy people changes as they age, and this may have an impact on disease development. In addition to the urinary tract microbiome’s role in maintaining good health, Changes in the composition of their microbial diversity have also been linked to various urinary diseases like prostatitis. Chronic prostatitis is a common condition in males (CP/CPPS), which is defined by persistent pain in the male perineum or Lower stomach area. Therefore, a better understanding of CPPS patients’ urinary microbiome condition would lead to a deeper comprehension of the pathogenesis and etiology of CP disease as well as fresh ideas for its treatment. Even in cases where the patients do not seem to suffer from bacterial kind of prostatitis, antibiotics therapy are frequently recommended. The continues of therapy is based on negative or positive response of patients. Although for the treatment of CP/CPPS a combination of three medications, including an antibiotic, an alpha-blocker, and a pain reliever or a nonsteroidal anti-inflammatory (NSAID), are used, none of them, even complex ones, is able to cure CPPS disease completely, which causes the periodic turning back of disorders as a chronic disease. Today, the urinary tract microbiota has been better characterized in comparison with traditional methods like culturing thanks to new sequencing methods like NGS (next-generation sequencing).
This narrative review’s goal is to explain the connections between chronic prostatitis disease and urine microbiome diversity and composition and discuss the links between immune system response and the local inflammation of CPPS. Additionally, a Ph.D. thesis project that is still in the process about metagenomic research on chronic prostatitis disease samples is mentioned in this article too.