The role of midkine in the inflammatory process and its correlation with other inflammatory markers in renal transplant recipients.

Uzun, Sami; Kaya, Burcu; Celik, Kenan; Behlul, Ahmet; Ozkan, Oktay; Kuvvet, Melike; Doventas, Yasemin; GÜRSU, Meltem; Karadag, Serhat; Sumnu, Abdullah; Cebeci, Egemen; Kocak, Burak; Turkmen, Aydın; Ozturk, Savaş

doi:10.5301/ijao.5000510

The role of midkine in the inflammatory process and its correlation with other inflammatory markers in renal transplant recipients.

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Uzun S., Kaya B., Celik K., Behlul A., Ozkan O., Kuvvet M., ...More

The International journal of artificial organs, vol.39, no.6, pp.277-81, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 39 Issue: 6
Publication Date: 2016
Doi Number: 10.5301/ijao.5000510
Journal Name: The International journal of artificial organs
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.277-81
Istanbul University Affiliated: Yes

Abstract

Background: Midkine (MK), which is expressed in the proximal tubular epithelial cells of the kidney, is thought to have a role in the pathophysiology of inflammation-related renal diseases. Both immunological and nonimmunological mechanisms may affect renal functions negatively during the early and late post-transplantation periods. We aimed in our study to evaluate the relationship of MK with clinical findings and inflammatory markers, including high sensitivity C-reactive protein (hs-CRP), interleukin (IL-6) and tumor necrosis factor (TNF-alpha) in the pretransplant and post-transplant period.