The role of midkine in the inflammatory process and its correlation with other inflammatory markers in renal transplant recipients.
The International journal of artificial organs, vol.39, no.6, pp.277-81, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 39 Issue: 6
- Publication Date: 2016
- Doi Number: 10.5301/ijao.5000510
- Journal Name: The International journal of artificial organs
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.277-81
- Istanbul University Affiliated: Yes
Abstract
Background: Midkine (MK), which is expressed in the proximal tubular epithelial cells of the kidney, is thought to have a role in the pathophysiology of inflammation-related renal diseases. Both immunological and nonimmunological mechanisms may affect renal functions negatively during the early and late post-transplantation periods. We aimed in our study to evaluate the relationship of MK with clinical findings and inflammatory markers, including high sensitivity C-reactive protein (hs-CRP), interleukin (IL-6) and tumor necrosis factor (TNF-alpha) in the pretransplant and post-transplant period.