Natural Products Mediated Regulation of Oxidative Stress and DNA Damage in Ultraviolet Exposed Skin Cells

Farooqi A. A., Li R., Huang H., Ismail M., Yuan S. F., Wang H. D., ...Daha Fazla

CURRENT PHARMACEUTICAL BIOTECHNOLOGY, cilt.16, sa.12, ss.1078-1084, 2015 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 12
  • Basım Tarihi: 2015
  • Doi Numarası: 10.2174/1389201016666150731111308
  • Dergi Adı: CURRENT PHARMACEUTICAL BIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1078-1084
  • Anahtar Kelimeler: Natural products, UV, oxidative stress, DNA damage, DNA repair, protection, miRNA, MICRORNA EXPRESSION, DERMAL FIBROBLASTS, EXTRACT PROTECTS, CANCER-CELLS, HACAT CELLS, IN-VITRO, UVB, REPAIR, KERATINOCYTES, E2F1
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Data obtained through high-throughput technologies have gradually revealed that a unique stratified epithelial architecture of human skin along with the antioxidant-response pathways provided vital defensive mechanisms against UV radiation. However, it is noteworthy that skin is a major target for toxic insult by UV radiations that can alter its structure and function. Substantial fraction of information has been added into the existing pool of knowledge related to natural products mediated biological effects in UV exposed skin cells. Accumulating evidence has started to shed light on the potential of these bioactive ingredients as protective natural products in cosmetics against UV photodamage by exerting biological effects mainly through wide ranging intracellular signalling cascades of oxidative stress and modulation of miRNAs. In this review, we have summarized recently emerging scientific evidences addressing underlying mechanisms of UV induced oxidative stress and deregulation of signalling cascades and how natural products can be used tactfully to protect against UV induced harmful effects.