Results of rhabdomyosarcoma treatment in a developing country

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Karakas Z., Agaoglu L., Biner B., Devecioglu O., Anak S., Yalman N., ...Daha Fazla

ACTA MEDICA OKAYAMA, cilt.54, sa.4, ss.173-177, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 4
  • Basım Tarihi: 2000
  • Dergi Adı: ACTA MEDICA OKAYAMA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.173-177
  • Anahtar Kelimeler: rhabdomyosarcoma, pediatric oncology, chemotherapy, SOFT-TISSUE SARCOMA, INTERGROUP RHABDOMYOSARCOMA, CHILDHOOD-CANCER, BIOLOGY
  • İstanbul Üniversitesi Adresli: Evet

Özet

Fifty-one children (median age: 4.5 years; 4 months-16 years) diagnosed with rhabdomyosarcoma were treated in our center between 1980-1999. The primary sites were head and neck in 31.4%, the genito-urinary system in 21.6%, and extremities in 9.8% of the patients. The histopathologic subtypes were embryonal in 80.4%, alveolar in 9.8%, and undifferentiated in 9.8%. The majority of the patients were considered group III (47%) and group IV (25.5%) according the criteria of the Intergroup Rhabdomyosarcoma Study (IRS). Primary total tumour resection was performed in only 27.5% of the patients. The patients were treated with assigned regimens of IRS II and IRS III protocols. Radiotherapy was applied to 92.1% of the patients. Thirty-four patients (66.7%) were lost to follow up, and of the remaining 17 patients, 7 patients (41.2%) died, relapse occurred in 9 patients (52.9%) and 10 patients (58.8%) are alive. The percentage of cases lost to follow up during the first 10 years and the following 9 years of the study were 77.4% and 50%, respectively. Incompliance with cancer treatment remains a major problem in developing countries.