In vitro activities of ceftazidime/avibactam alone or in combination with antibiotics against multidrug-resistant Acinetobacter baumannii isolates


Kara E., Yilmaz M., Celik B. O.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, vol.17, pp.137-141, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jgar.2018.12.004
  • Journal Name: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.137-141
  • Keywords: Ceftazidime/avibactam, Combination, beta-Lactam inhibitors, Gram-negative, Synergy, TIME-KILL, COLISTIN, TIGECYCLINE, INFECTIONS, EMERGENCE, IMIPENEM, AGENTS
  • Istanbul University Affiliated: Yes

Abstract

Objectives: Infections caused by multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) are a growing problem because of the limited options for treatment. The number of antimicrobials that are currently being developed is still insufficient to control this global threat. Combination therapies of antibiotics with different antimicrobial mechanisms have been proposed as the best options for treating MDR A. baumannii infections. The objective of this study was to investigate the in-vitro effectiveness of ceftazidime/avibactam alone or in combination with antibiotics against MDR A. baumannii isolates using time-kill assays.