A Novel Perspective for Alzheimer's Disease: Vitamin D Receptor Suppression by Amyloid-beta and Preventing the Amyloid-beta Induced Alterations by Vitamin D in Cortical Neurons

Dursun E., Gezen-Ak D., Yilmazer S.

JOURNAL OF ALZHEIMERS DISEASE, cilt.23, sa.2, ss.207-219, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3233/jad-2010-101377
  • Dergi Adı: JOURNAL OF ALZHEIMERS DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.207-219
  • İstanbul Üniversitesi Adresli: Evet

Özet

Amyloid-beta (A beta) is the core component of amyloid plaques of Alzheimer's disease (AD). The effects of A beta include damage to neuronal plasma membrane, disruption of Ca2+ homeostasis, and alterations of neurotrophic factor levels. The aim of this study was to determine the effects of A beta treatment on vitamin D receptor (VDR), L-type voltage sensitive calcium channels A1C (LVSCC A1C), NGF, and observing the effects of vitamin D treatment on A beta induced alterations in primary cortical neurons. As to the latter, we aimed to test the suggested neuroprotective role of vitamin D as a neglected neurosteroid.