Pineal Gland Activity in Advanced-Stage Pediatric Neuroblastoma Patients on 68 Ga-DOTATATE PET/CT.

Isik E. G., Denizmen D., Arslan D. F., Simsek D. H., Özkan Z. G.

Clinical nuclear medicine, vol.50, no.4, pp.343-345, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 4
  • Publication Date: 2025
  • Doi Number: 10.1097/rlu.0000000000005626
  • Journal Name: Clinical nuclear medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Page Numbers: pp.343-345
  • Keywords: 68Ga-DOTATATE PET/CT, neuroblastoma, pineal gland, SSTR
  • Istanbul University Affiliated: Yes

Abstract

Neuroblastoma is the most common malignancy in infants and the most common extracranial solid tumor accounting for approximately 6% of pediatric cancer. Although surgical intervention serves as the primary treatment for early-stage disease, advanced-stage cases necessitate a variety of oncologic therapeutic approaches, including 131I-MIBG and peptide receptor radionuclide therapy. Herein we report incidental pineal gland activity, represented in 68Ga-DOTATATE PET/CT (SSTR-PET) in 3 pediatric patients diagnosed with stage 4 neuroblastoma, related to the physiological distribution of radiopharmaceuticals.