TNF-α-308 G/A variant may be associated with bipolar disorder in a Turkish population


Nursal A. F. , Aytac H. M. , Ciftci H. S. , Yazar M. S. , Oyaci Y., Pehlivan M., ...More

Revista de Psiquiatria Clinica, vol.47, no.6, pp.176-179, 2020 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 6
  • Publication Date: 2020
  • Doi Number: 10.15761/0101-60830000000258
  • Title of Journal : Revista de Psiquiatria Clinica
  • Page Numbers: pp.176-179
  • Keywords: Bipolar disorder, tumor necrosis factor alpha, variant, PCR-RFLP, NECROSIS-FACTOR-ALPHA, TNF-ALPHA, PROMOTER POLYMORPHISM, GENE POLYMORPHISM, SCHIZOPHRENIA, RISK, METAANALYSIS, DEPRESSION, CYTOKINES, IL-10

Abstract

© 2020, UNIV SAOPAULO. All rights reserved.Background: Tumor necrosis factor alpha (TNF-α) is a proinflammatory multifunctional cytokine produced by macrophages. A dysregulation of the immune system contribute to the pathogenesis of bipolar disorder (BD). In this study, we aimed to investigate the relationship between the TNF-α gene -308G/A promoter variant and the risk of BD. Methods: A total of 104 BD patients and 94 healthy controls were enrolled in the study. Genomic DNA was isolated and TNF-α -308G/A variant was analyzed using PCR-RFLP method. Results: TNF-α -308G/A variant GG genotype and G allele were more prevalent in BD patients compared to the controls (p = 0.002 and p = 0.017, respectively). The patients carrying GG genotype had a 5.927-fold higher risk of developing BD. Then, we divided patients into two groups as smokers and non-smokers. TNF-α -308G/A variant GA genotype was higher in non-smoker BD patients than smoker patients (p = 0.027). We found that TNF-α -308G/A AA genotype and A allele increased in smoker patients compared to non-smoker patients (p = 0.008, p = 0.002, respectively). Discussion: Our results provided evidence that TNF-α -308G/A variant may contribute to development of BD in a Turkish cohort. In addition, this variant plays a relevant role in the smoker status of BD.