Protective effects of onion (Allium cepa) extract against doxorubicin-induced hepatotoxicity in rats
TOXICOLOGY AND INDUSTRIAL HEALTH, vol.32, no.3, pp.551-557, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 32 Issue: 3
- Publication Date: 2016
- Doi Number: 10.1177/0748233713504807
- Journal Name: TOXICOLOGY AND INDUSTRIAL HEALTH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.551-557
- Keywords: Acute toxicity, animal model, liver, hepatic toxicity, anti-inflammatory, LIPID-PEROXIDATION, ADRIAMYCIN, CARDIOTOXICITY, TOXICITY, LIVER, GLUTATHIONE, INHIBITION, ERDOSTEINE, NICOTINE, ACID
- Istanbul University Affiliated: No
Abstract
Background/aim: Doxorubicin (DOX) is a widely used and potent chemotherapeutic agent. However, serious dose-limiting toxicity through generation of free oxygen radicals is a commonly encountered clinical problem. The aim of the current study was to assess the protective role of onion (Allium cepa) extract (ACE) against DOX-induced hepatotoxicity in rats.