Protective effects of onion (Allium cepa) extract against doxorubicin-induced hepatotoxicity in rats

Mete R., Oran M., Topcu B., Oznur M., Seber E. S., GEDİKBAŞI A., ...Daha Fazla

TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.32, sa.3, ss.551-557, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1177/0748233713504807
  • Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.551-557
  • Anahtar Kelimeler: Acute toxicity, animal model, liver, hepatic toxicity, anti-inflammatory, LIPID-PEROXIDATION, ADRIAMYCIN, CARDIOTOXICITY, TOXICITY, LIVER, GLUTATHIONE, INHIBITION, ERDOSTEINE, NICOTINE, ACID
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Background/aim: Doxorubicin (DOX) is a widely used and potent chemotherapeutic agent. However, serious dose-limiting toxicity through generation of free oxygen radicals is a commonly encountered clinical problem. The aim of the current study was to assess the protective role of onion (Allium cepa) extract (ACE) against DOX-induced hepatotoxicity in rats.