Protective effects of onion (Allium cepa) extract against doxorubicin-induced hepatotoxicity in rats

Mete, Rafet; Oran, Mustafa; Topcu, Birol; Oznur, Meltem; Seber, Erdogan; GEDİKBAŞI, Asuman; Yetisyigit, Tarkan

doi:10.1177/0748233713504807

Protective effects of onion (Allium cepa) extract against doxorubicin-induced hepatotoxicity in rats

Mete R., Oran M., Topcu B., Oznur M., Seber E. S. , GEDİKBAŞI A. , ...More

TOXICOLOGY AND INDUSTRIAL HEALTH, vol.32, no.3, pp.551-557, 2016 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 32 Issue: 3
Publication Date: 2016
Doi Number: 10.1177/0748233713504807
Title of Journal : TOXICOLOGY AND INDUSTRIAL HEALTH
Page Numbers: pp.551-557

Abstract

Background/aim: Doxorubicin (DOX) is a widely used and potent chemotherapeutic agent. However, serious dose-limiting toxicity through generation of free oxygen radicals is a commonly encountered clinical problem. The aim of the current study was to assess the protective role of onion (Allium cepa) extract (ACE) against DOX-induced hepatotoxicity in rats.