Protective effects of onion (Allium cepa) extract against doxorubicin-induced hepatotoxicity in rats
TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.32, sa.3, ss.551-557, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 3
- Basım Tarihi: 2016
- Doi Numarası: 10.1177/0748233713504807
- Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.551-557
- Anahtar Kelimeler: Acute toxicity, animal model, liver, hepatic toxicity, anti-inflammatory, LIPID-PEROXIDATION, ADRIAMYCIN, CARDIOTOXICITY, TOXICITY, LIVER, GLUTATHIONE, INHIBITION, ERDOSTEINE, NICOTINE, ACID
- İstanbul Üniversitesi Adresli: Hayır
Özet
Background/aim: Doxorubicin (DOX) is a widely used and potent chemotherapeutic agent. However, serious dose-limiting toxicity through generation of free oxygen radicals is a commonly encountered clinical problem. The aim of the current study was to assess the protective role of onion (Allium cepa) extract (ACE) against DOX-induced hepatotoxicity in rats.