Dose-dependent ultrastructural and morphometric alterations after erythropoietin treatment in rat femoral artery vasospasm model

Ulusal I., Tari R., Ozturk G., Aycicek E., Aktar F., Kotil K., ...Daha Fazla

ACTA NEUROCHIRURGICA, cilt.152, sa.12, ss.2161-2166, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 152 Sayı: 12
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s00701-010-0775-6
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2161-2166
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Cerebral vasospasm is the common cause of poor outcome after aneurysmal subarachnoid hemorrhage (aSAH). Although many agents are experimentally and clinicaly used to protect or recover from vasospasm, an effective neurotherapeutic drug is still missing. Erythropoietin (EPO) is recently a promising candidate. The aim of this study is to investigate the dose-dependent effects of recombinant human EPO (rhEPO) on arterial wall in a rat femoral artery vasospasm model.