Long Remission in Muscle-Specific Kinase Antibody-Positive Juvenile Myasthenia

Anlar B., Yilmaz V., Saruhan-Direskeneli G.

PEDIATRIC NEUROLOGY, cilt.40, sa.6, ss.455-456, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 6
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.pediatrneurol.2008.11.014
  • Dergi Adı: PEDIATRIC NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.455-456
  • İstanbul Üniversitesi Adresli: Evet

Özet

The clinical course of anti-muscle specific kinase-positive myasthenia in children has been little reported. Described here is the case of an 8 year-old boy who presented with ptosis and generalized weakness, which resolved within I month without any immunomodulatory treatment. This spontaneous remission lasted 6 years and was then followed by a relapse with bulbar symptoms. The patient was put on plasmapheresis; after initial benefit, symptoms worsened and serum antibody levels persisted. This case constitutes an example of the variability of the clinical presentation, course, and therapeutic response in anti-muscle specific kinase-positive myasthenia in childhood. (C) 2009 by Elsevier Inc. All rights reserved.