No Activating Mutations of FSH Receptor in Four Children with Ovarian Juvenile Granulosa Cell Tumors and the Association of These Tumors with Central Precocious Puberty

Bas, Firdevs; Pescovitz, Ora; Steinmetz, Rosemary

doi:10.1016/j.jpag.2008.10.003

No Activating Mutations of FSH Receptor in Four Children with Ovarian Juvenile Granulosa Cell Tumors and the Association of These Tumors with Central Precocious Puberty

Atıf İçin Kopyala

Bas F., Pescovitz O. H., Steinmetz R.

JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY, cilt.22, sa.3, ss.173-179, 2009 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 22 Sayı: 3
Basım Tarihi: 2009
Doi Numarası: 10.1016/j.jpag.2008.10.003
Dergi Adı: JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.173-179
Anahtar Kelimeler: Activating mutation, Follicle-stimulating hormone receptor, Central precocious puberty, Children, Granulosa cell tumor, FOLLICLE-STIMULATING-HORMONE, BINDING-SITES, GONADOTROPIN, GENE, FAILURE, PSEUDOPUBERTY, ADOLESCENTS, NEOPLASMS, CLONING, WOMEN
İstanbul Üniversitesi Adresli: Evet

Özet

Study Objective: The stimulation of the follicle-stimulating hormone receptor (FSHR) by circulating FSH or some activating mutations of the FSHR may play a causal role in the development of granulosa cell tumors of ovaries.