No Activating Mutations of FSH Receptor in Four Children with Ovarian Juvenile Granulosa Cell Tumors and the Association of These Tumors with Central Precocious Puberty


Bas F. , Pescovitz O. H. , Steinmetz R.

JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY, vol.22, no.3, pp.173-179, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.1016/j.jpag.2008.10.003
  • Title of Journal : JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
  • Page Numbers: pp.173-179
  • Keywords: Activating mutation, Follicle-stimulating hormone receptor, Central precocious puberty, Children, Granulosa cell tumor, FOLLICLE-STIMULATING-HORMONE, BINDING-SITES, GONADOTROPIN, GENE, FAILURE, PSEUDOPUBERTY, ADOLESCENTS, NEOPLASMS, CLONING, WOMEN

Abstract

Study Objective: The stimulation of the follicle-stimulating hormone receptor (FSHR) by circulating FSH or some activating mutations of the FSHR may play a causal role in the development of granulosa cell tumors of ovaries.