The Association of ABCC5 and ABCC11 Polymorphisms with The Pharmacokinetics of 5-FU in Advanced Gastric Cancer Patients


Kara Z. P. , Oztas E. , ÖZTÜRK D., Akyel Y. K. , Turna H., Okyar A. , ...Daha Fazla

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.10, ss.285-291, 2020 (ESCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 10 Konu: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.33808/clinexphealthsci.757619
  • Dergi Adı: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
  • Sayfa Sayıları: ss.285-291

Özet

Objective: Gastric cancer is the second leading cause of cancer-related deaths worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used drugs to treat cancer, but 5-FU and its forms are characterized by wide inter-individual pharmacokinetic variability. ABCC5 and ABCC11 are members of the ABC transporter superfamily and play a role in the efflux of antineoplastic drugs like 5-FU.