The Association of ABCC5 and ABCC11 Polymorphisms with The Pharmacokinetics of 5-FU in Advanced Gastric Cancer Patients
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, vol.10, no.3, pp.285-291, 2020 (ESCI, TRDizin)
- Publication Type: Article / Article
- Volume: 10 Issue: 3
- Publication Date: 2020
- Doi Number: 10.33808/clinexphealthsci.757619
- Journal Name: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
- Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Page Numbers: pp.285-291
- Istanbul University Affiliated: Yes
Abstract
Objective: Gastric cancer is the second leading cause of cancer-related deaths worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used drugs to treat cancer, but 5-FU and its forms are characterized by wide inter-individual pharmacokinetic variability. ABCC5 and ABCC11 are members of the ABC transporter superfamily and play a role in the efflux of antineoplastic drugs like 5-FU.