The Association of ABCC5 and ABCC11 Polymorphisms with The Pharmacokinetics of 5-FU in Advanced Gastric Cancer Patients

Kara Z., Oztas E., ÖZTÜRK D., Akyel Y. K., Turna H., Okyar A., ...More

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, vol.10, no.3, pp.285-291, 2020 (ESCI) identifier


Objective: Gastric cancer is the second leading cause of cancer-related deaths worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used drugs to treat cancer, but 5-FU and its forms are characterized by wide inter-individual pharmacokinetic variability. ABCC5 and ABCC11 are members of the ABC transporter superfamily and play a role in the efflux of antineoplastic drugs like 5-FU.