The Association of ABCC5 and ABCC11 Polymorphisms with The Pharmacokinetics of 5-FU in Advanced Gastric Cancer Patients

Kara, ZELİHA; Oztas, EZGİ; ÖZTÜRK, DİLEK; Akyel, Yasemin; Turna, Hande; Okyar, ALPER; Ozhan, GÜL

doi:10.33808/clinexphealthsci.757619

The Association of ABCC5 and ABCC11 Polymorphisms with The Pharmacokinetics of 5-FU in Advanced Gastric Cancer Patients

Kara Z., Oztas E., ÖZTÜRK D., Akyel Y. K., Turna H., Okyar A., ...Daha Fazla

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.10, sa.3, ss.285-291, 2020 (ESCI, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 10 Sayı: 3
Basım Tarihi: 2020
Doi Numarası: 10.33808/clinexphealthsci.757619
Dergi Adı: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.285-291
İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Gastric cancer is the second leading cause of cancer-related deaths worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used drugs to treat cancer, but 5-FU and its forms are characterized by wide inter-individual pharmacokinetic variability. ABCC5 and ABCC11 are members of the ABC transporter superfamily and play a role in the efflux of antineoplastic drugs like 5-FU.