Simultaneous Determination of Fat-Soluble Vitamins by Using Modified Glassy Carbon Electrode

AVAN A. A., Filik H.

RUSSIAN JOURNAL OF ELECTROCHEMISTRY, vol.57, no.8, pp.858-871, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 8
  • Publication Date: 2021
  • Doi Number: 10.1134/s1023193521080048
  • Journal Name: RUSSIAN JOURNAL OF ELECTROCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aqualine, Chemical Abstracts Core, Chimica, Compendex, Environment Index, INSPEC
  • Page Numbers: pp.858-871
  • Keywords: vitamin A, vitamin D, vitamin E, vitamin K, fat-soluble vitamin, voltammetry, food analysis, ALPHA-TOCOPHEROL, VOLTAMMETRIC DETERMINATION, ELECTROCHEMICAL DETERMINATION, VEGETABLE-OILS, STRIPPING VOLTAMMETRY, LIQUID-CHROMATOGRAPHY, WATER, SOLUBILIZATION, BEHAVIOR, RETINOL
  • Istanbul University Affiliated: Yes

Abstract

This study demonstrates the development of an electrochemical sensor based on beta-cyclodextrin/multi-wall carbon nanotubes modified glassy carbon electrode for detecting fat-soluble vitamins (vitamin A, vitamin D-3, vitamin E and vitamin K-1) in an aqueous media of micellar solutions using voltammetric studies. The linear calibration curves were 8-100, 0.8-60, 0.5-60 and 0.1-20 mu M for vitamin A, vitamin D-3, vitamin E and vitamin K-1, respectively. The optimal conditions for quantitative determination were obtained in a Britton-Robinson buffer at pH 5.0. Moreover, it is found that beta-cyclodextrin/multi-wall carbon nanotubes displays high reproducibility and selectivity for the determination of fat-soluble vitamins. The proposed voltammetric method permits the rapid and simple simultaneous electrochemical determination of fat-soluble vitamins. In this study, we used a sample pre-treatment methods, liquid-liquid extraction with hexane. At the end of the study, the proposed approach was applied to the electrochemical simultaneous determination of the mixed pharmaceutical sample and milk sample.