A patient with encephalitis associated with NMDA receptor antibodies


SANSING L. H. , Tuzun E. , KO M. W. , BACCON J., LYNCH D. R. , DALMAU J.

NATURE CLINICAL PRACTICE NEUROLOGY, vol.3, no.5, pp.291-296, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 5
  • Publication Date: 2007
  • Doi Number: 10.1038/ncpneuro0493
  • Title of Journal : NATURE CLINICAL PRACTICE NEUROLOGY
  • Page Numbers: pp.291-296

Abstract

Background A 34-year-old woman presented with headache, feverish sensation and anxiety, rapidly followed by homicidal ideation, aggressive agitation, seizures, hypoventilation, hyperthermia and prominent autonomic instability requiring intubation and sedation. She developed episodes of hypotension and bradycardia with periods of asystole lasting up to 15 seconds. Upon weaning off sedation, her eyes opened but she was unresponsive to stimuli. There was muscle rigidity, frequent facial grimacing, rhythmic abdominal contractions, kicking motions of the legs, and intermittent dystonic postures of the right arm.