Thrombolytic Therapy for the Treatment of Prosthetic Heart Valve Thrombosis in Pregnancy With Low-Dose, Slow Infusion of Tissue-Type Plasminogen Activator

Ozkan M., Cakal B., Karakoyun S., Gursoy O. M. , Cevik C., Kalcik M., ...More

CIRCULATION, vol.128, no.5, pp.532-542, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 128 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.1161/circulationaha.113.001145
  • Title of Journal : CIRCULATION
  • Page Numbers: pp.532-542


Background-Prosthetic valve thrombosis during pregnancy is life-threatening for mother and fetus, and the treatment of this complication is unclear. Cardiac surgery in pregnancy is associated with very high maternal and fetal mortality and morbidity. Thrombolytic therapy has rarely been used in these patients. The aim of this study is to evaluate the safety and efficacy of low-dose (25 mg), slow infusion (6 hours) of tissue-type plasminogen activator for the treatment of prosthetic valve thrombosis in pregnant women.