SUPPRESSION OF ATHEROGENESIS BY N-3 FATTY-ACIDS IN THE CHOLESTEROL-FED RABBIT


DEMIROGLU C., OZDER A. B. , ALTUG T. , ORBAY B., SATARYILDIRIM S., BILIR A. , ...Daha Fazla

ANGIOLOGY, cilt.42, ss.323-330, 1991 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 42 Konu: 4
  • Basım Tarihi: 1991
  • Doi Numarası: 10.1177/000331979104200410
  • Dergi Adı: ANGIOLOGY
  • Sayfa Sayıları: ss.323-330

Özet

The effects of n-3 fatty-acid supplementation on serum lipids, platelet aggregation, and the development of atherosclerotic lesions were studied in the cholesterol-fed rabbit. Serum total cholesterol and LDL cholesterol values were significantly reduced in comparison with those of the nonsupplemented cholesterol-fed group (p < 0.005, p < 0.0025, respectively), though still higher than those of the control group (p < 0.0025, p < 0.0125 respectively). Platelet aggregation was reduced below that of the cholesterol-fed and the control levels (p < 0.0005, p < 0.0025, respectively). The endothelial injury encountered in cholesterol-fed rabbits was inhibited in the supplemented group. It is concluded that n-3 fatty acids suppress atherogenesis in this animal model by interfering with platelet aggregation and lipid metabolism.