Utility of Serum and Urine uPAR Levels for Diagnosis of Breast Cancer

Soydinc H. O., Duranyildiz D., Guney N., Derin D., Yasasever V.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, cilt.13, sa.6, ss.2887-2889, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.7314/apjcp.2012.13.6.2887
  • Dergi Adı: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2887-2889
  • Anahtar Kelimeler: Tumor markers, biochemical markers, breast cancer, cancer biomarkers, invasion & metastasis, uPAR, PLASMINOGEN-ACTIVATOR RECEPTOR, TUMOR-MARKERS, SYSTEM, CARCINOMA, TISSUE, EXPRESSION, MORTALITY
  • İstanbul Üniversitesi Adresli: Evet

Özet

Malignant tumors have a capacity to degrade the extracellular matrix by controlled proteolysis. One system involved in these processes is the urokinase-type plasminogen activator (uPA) system. uPAR levels are elevated in tumors from several types of cancer. Our study was planned to investigate serum and urine levels of uPAR in breast cancer patients (n=180) and healthy controls (n=60) by ELISA. Serum (p<0.001) and urine (p<0.001) uPAR values in the patients were both significantly elevated. High serum and urine levels of uPAR can be used as diagnostic tools in lymph node positive patients.