Clinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment

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Sen S., Ahmad Y., Dehbi H., Howard J. P., Iglesias J. F., Al-Lamee R., ...More

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol.73, no.4, pp.444-453, 2019 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 73 Issue: 4
• Publication Date: 2019
• Doi Number: 10.1016/j.jacc.2018.10.070
• Journal Name: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.444-453
• Istanbul University Affiliated: Yes

Abstract

BACKGROUND Physicians are not always comfortable deferring treatment of a stenosis in the left anterior descending (LAD) artery because of the perception that there is a high risk of major adverse cardiac events (MACE). The authors describe, using the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation) trial, MACE rates when LAD lesions are deferred, guided by physiological assessment using fractional flow reserve (FFR) or the instantaneous wave-free ratio (iFR).