Examining facial emotion recognition as an intermediate phenotype for psychosis: Findings from the EUGEI study

Fusar-Poli L., Pries L., van Os J., Erzin G., Delespaul P., Kenis G., ...Daha Fazla

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, cilt.113, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 113
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.pnpbp.2021.110440
  • Dergi Adı: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Animal Behavior Abstracts, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Anahtar Kelimeler: Schizophrenia, Emotion, Social cognition, Schizotypal traits, Polygenic risk score, SOCIAL COGNITION, STRUCTURED INTERVIEW, UNAFFECTED SIBLINGS, POLYGENIC RISK, GENETIC RISK, SCHIZOPHRENIA, INDIVIDUALS, ASSOCIATION, RELIABILITY, IMPUTATION
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Social cognition impairments, such as facial emotion recognition (FER), have been acknowledged since the earliest description of schizophrenia. Here, we tested FER as an intermediate phenotype for psychosis using two approaches that are indicators of genetic risk for schizophrenia: the proxy-genetic risk approach (family design) and the polygenic risk score for schizophrenia (PRS-SCZ).