Intrathecal methotrexate-induced acute cerebellar syndrome

Ferhanoglu B., Ongoren S., Ar C., Uzel B., Forta H., Necioglu D.

ANNALS OF HEMATOLOGY, vol.82, no.4, pp.241-243, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 82 Issue: 4
  • Publication Date: 2003
  • Doi Number: 10.1007/s00277-003-0618-0
  • Journal Name: ANNALS OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.241-243
  • Istanbul University Affiliated: Yes

Abstract

Intrathecal application of chemotherapeutics has been the mainstay of central nervous system prophylaxis in acute lymphoblastic leukemia treatment. We describe a patient who developed acute cerebellar syndrome after prophylactic intrathecal methotrexate administration and recovered spontaneously. To our knowledge, this is the first case of methotrexate-related acute cerebellar syndrome.