The Association Between Serum Levels of Glial Biomarkers, Clinical Severity and Electro-encephalography Features in Idiopathic West and Lennox-Gastaut Syndromes

Charkazzade M., Soylu S., Tüzün E., Yılmaz V., Sezgin M., Yapıcı Z., ...Daha Fazla

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, cilt.61, sa.2, ss.128-134, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 2
  • Basım Tarihi: 2024
  • Doi Numarası: 10.29399/npa.28669
  • Dergi Adı: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, Psycinfo, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.128-134
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Introduction: Although the contribution of enhanced glial activity in seizure induction is increasingly recognized, the role of glia-induced neuroinflammation in the physiopathology of epileptic encephalopathy Methods: To delineate the contribution of glial activity in EE, we measured levels of glia-derived mediators with previously described mobility group box 1 (HMGB1), chitinase-3-like protein 1 (CHI3L1), soluble CD163 (sCD163) and triggering receptor expressed on myeloid cells 2 (TREM2) by ELISA in sera of patients with idiopathic West Results: Patients with EE showed significantly higher CHI3L1 levels