Association of Familial Mediterranean Fever-Related MEFV Variations With Ankylosing Spondylitis


Cosan F., Ustek D., Oku B., Duymaz-Tozkir J., Cakiris A. , Abaci N. , ...More

ARTHRITIS AND RHEUMATISM, vol.62, no.11, pp.3232-3236, 2010 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 11
  • Publication Date: 2010
  • Doi Number: 10.1002/art.27683
  • Journal Name: ARTHRITIS AND RHEUMATISM
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.3232-3236

Abstract

Objective. The pathogenesis of ankylosing spondylitis (AS) has a strong genetic contribution. Familial Mediterranean fever (FMF) is an autosomal recessively inherited autoinflammatory disorder caused by MEFV gene missense variations, and a clinical association between FMF and AS has been reported previously. The aim of this study was to analyze the association of common MEFV variations (M694V, M680I, V726A, and E148Q) with AS in a group of Turkish patients.