Association of Familial Mediterranean Fever-Related MEFV Variations With Ankylosing Spondylitis

Cosan F., Ustek D., Oku B., Duymaz-Tozkir J., Cakiris A. , Abaci N. , ...Daha Fazla

ARTHRITIS AND RHEUMATISM, cilt.62, ss.3232-3236, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 62 Konu: 11
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1002/art.27683
  • Sayfa Sayıları: ss.3232-3236


Objective. The pathogenesis of ankylosing spondylitis (AS) has a strong genetic contribution. Familial Mediterranean fever (FMF) is an autosomal recessively inherited autoinflammatory disorder caused by MEFV gene missense variations, and a clinical association between FMF and AS has been reported previously. The aim of this study was to analyze the association of common MEFV variations (M694V, M680I, V726A, and E148Q) with AS in a group of Turkish patients.