INFLUENCE OF THYMIC FRACTION-5 ON ERYTHROCYTE (NA++K+)-ATPASE ACTIVITY IN HYPERCHOLESTEROLEMIC RABBITS

GOKKUSU C., OZ H.

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, vol.60, no.4, pp.398-401, 1990 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 4
  • Publication Date: 1990
  • Journal Name: INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.398-401
  • Istanbul University Affiliated: No

Abstract

The effects of thymus fraction 5 injection on cholesterol, triglyceride and phospholipid levels in plasma and erythrocytes as well as on membrane-bound (Na+ + K+)-ATPase activity were investigated in rabbits fed a high-cholesterol diet for 3 months. While cholesterol feeding caused an increase in plasma and erythrocytes phospholipid levels, (Na+ + K+)-ATPase activity was found to be reduced. After high-cholesterol diet, the rabbits were given normal diet with or without thymosin F5 injections every other day for 21 days. Thymosin F5 treatment caused a significant decrease in plasma and erythrocyte phospholipid levels whereas membrane-bound (Na+ + K+)-ATPase activity was increased significantly. It is concluded that hypercholesterolemic lesions and the decreased erythrocyte ATPase activity may be eliminated by thymic extracts in rabbits.