A new approach for the synthesis of N,N '-bis(phenoxyacetyl)hydrazines

Apaydin Ç. B. , Cesur Z.

ISTANBUL JOURNAL OF PHARMACY, cilt.49, sa.2, ss.61-63, 2019 (ESCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Konu: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.26650/istanbuljpharm.2019.19002
  • Sayfa Sayıları: ss.61-63


This report is about an unexpected formation of N, N'-bis(substituted phenoxyacetyl) hydrazine derivatives. The reaction between N'-(4-ethylcyclohexylidene) phenoxyacetohydrazide with sulfanyl acids to obtain 4-thiazolidinones s, gave an unexpected product, N, N'-bis(phenoxyacetyl) hydrazine, with high purity instead of the expected cyclocondensation product. When repeating the reaction with p-toluenesulfonic acid under the same conditions, the reaction resulted in the same compound. This indicates that two molecules of N'-(4-ethylcyclohexylidene) phenoxyacetohydrazide were involved in the reaction. The reaction can be applied as a different and new procedure for the synthesis of several N, N'-bis(substituted phenoxyacetyl) hydrazine derivatives.