Isolation and characterization of bacteriophage SA-19 and investigation of antibiofilm effect against clinical strains

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Damar Çelik D., ÖZBEK ÇELİK B.

Journal of Research in Pharmacy, cilt.28, sa.2, ss.505-515, 2024 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 2024
  • Doi Numarası: 10.29228/jrp.714
  • Dergi Adı: Journal of Research in Pharmacy
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.505-515
  • Anahtar Kelimeler: bacteriophage, biofilm, Phage-antibiotic combination, Staphylococcus aureus
  • İstanbul Üniversitesi Adresli: Evet

Özet

Because the emergence of antimicrobial resistance worldwide and alternative treatment strategies against Staphylococcus aureus infections are still being sought, we investigated a new bacteriophage with a lytic effect against S. aureus strains in this study. Then, we isolated potentially therapeutic lytic S. aureus phage from seawater and determined the biological characterization and in vitro lytic effect against various clinical bacterial strains. As a result, our study provides evidence of phage application for S. aureus strains, combination studies with conventional antibiotics as an alternative treatment option in clinical.