Isolation and characterization of bacteriophage SA-19 and investigation of antibiofilm effect against clinical strains

Creative Commons License

Damar Çelik D., ÖZBEK ÇELİK B.

Journal of Research in Pharmacy, vol.28, no.2, pp.505-515, 2024 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2024
  • Doi Number: 10.29228/jrp.714
  • Journal Name: Journal of Research in Pharmacy
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.505-515
  • Keywords: bacteriophage, biofilm, Phage-antibiotic combination, Staphylococcus aureus
  • Open Archive Collection: AVESIS Open Access Collection
  • Istanbul University Affiliated: Yes

Abstract

Because the emergence of antimicrobial resistance worldwide and alternative treatment strategies against Staphylococcus aureus infections are still being sought, we investigated a new bacteriophage with a lytic effect against S. aureus strains in this study. Then, we isolated potentially therapeutic lytic S. aureus phage from seawater and determined the biological characterization and in vitro lytic effect against various clinical bacterial strains. As a result, our study provides evidence of phage application for S. aureus strains, combination studies with conventional antibiotics as an alternative treatment option in clinical.