Impact of GLP-1 Analogue on Oxidative Damage and Hepatic Regeneration in Experimental 70% Hepatectomy Model

Battal M., Citgez B., Kartal A., Kemik A., Yildirim P., Ozdenkaya Y., ...More

HEPATO-GASTROENTEROLOGY, vol.62, no.138, pp.257-260, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 138
  • Publication Date: 2015
  • Doi Number: 10.5754/hge14958
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.257-260
  • Istanbul University Affiliated: Yes


Background/Aims: The purpose of our study is researching into impact of glucagon like peptide 1 (GLP 1) analogue on liver regeneration after major hepatectomy. Methodology: 24 wistar albino rats were consecutively divided into 3 groups. Group 1: Control (sham) group day 14 (n=8), Group 2: Liver resection group day 14 (n=8); 70% Liver resection was performed, Group 3: Study group day 14 (n=8); Subsequent to performing 70% liver resection, GLP-1 analogue was administered 2 times a day (10 mu gr/70 kg x 2 times). After 14 day, rats were sacrificed. Oxidative stress and antioxidant enzymes and mitochondrial permeability transition, cytochrome-c, Bax, Bcl-2, caspase-3, caspase-8 and caspase-3 activity were examined. Results: 70% Liver resection induced oxidative stress of liver tissue was ameliorated by GLP 1 induction. Administration of GLP increased Bcl-2 expression. Decreased expression of cytochrome-c was accompanied by a decrease caspase-3, caspase-8, and Bax expression and caspase-3 activity. Conclusions: Glp 1 induction plays a regenerative role in the major hepatectomy. This effect is dependent on modulation of the antiapoptotic and antioxidative pathways by GLP 1 expression.