Radioprotective Effects of Amifostine, L-Carnitine and Vitamin E in Preventing Early Salivary Gland Injury due to Radioactive Iodine Treatment

Torun N., Muratli A., Serim B. D., Ergulen A., Altun G. D.

CURRENT MEDICAL IMAGING REVIEWS, cilt.15, sa.4, ss.395-404, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 15 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1573405614666180314150808
  • Dergi Adı: CURRENT MEDICAL IMAGING REVIEWS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.395-404
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Standard treatment of differentiated thyroid cancer includes total thyroidectomy and high-dose Radioactive Iodine Therapy (RIT) for ablation of remnant thyroid tissue. When administered systemically, RIT can cause radiation-induced damage in non-targeted normal tissues. The aim of the present study was to compare the protective effects of amifostine (AMI), L-Carnitine (LC), and Vitamin E (EVIT) against high dose radioactive iodine treatment induced Salivary Gland (SG) damage using SG scintigraphy and histopathological examination.