Hyperbaric oxygen treatment reduces carrageenan-induced acute inflammation in rats


Sumen G., Cimsit M., Eroglu L.

EUROPEAN JOURNAL OF PHARMACOLOGY, vol.431, no.2, pp.265-268, 2001 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 431 Issue: 2
  • Publication Date: 2001
  • Doi Number: 10.1016/s0014-2999(01)01446-7
  • Title of Journal : EUROPEAN JOURNAL OF PHARMACOLOGY
  • Page Numbers: pp.265-268

Abstract

The present study was designed to assess the anti-inflammatory activity of hyperbaric oxygen treatment by comparing it with that of diclofenac, a nonsteroidal anti-inflammatory drug, and also to investigate whether hyperbaric oxygen treatment enhances the anti-inflammatory effect of diclofenac in carrageenan-induced paw edema which is commonly employed as an acute inflammation model in rats. Hyperbaric oxygen treatment and diclofenac (20 mg/kg) markedly reduced the carrageenan-induced paw edema in rats. In other words, they displayed anti-inflammatory activity. On the other hand, hyperbaric oxygen treatment did not consistently modify the anti-inflammatory effect of diclofenac in this model. (C) 2001 Elsevier Science B.V. All rights reserved.