Hyperbaric oxygen treatment reduces carrageenan-induced acute inflammation in rats

Sumen G., Cimsit M., Eroglu L.

EUROPEAN JOURNAL OF PHARMACOLOGY, cilt.431, ss.265-268, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 431 Konu: 2
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0014-2999(01)01446-7
  • Sayfa Sayıları: ss.265-268


The present study was designed to assess the anti-inflammatory activity of hyperbaric oxygen treatment by comparing it with that of diclofenac, a nonsteroidal anti-inflammatory drug, and also to investigate whether hyperbaric oxygen treatment enhances the anti-inflammatory effect of diclofenac in carrageenan-induced paw edema which is commonly employed as an acute inflammation model in rats. Hyperbaric oxygen treatment and diclofenac (20 mg/kg) markedly reduced the carrageenan-induced paw edema in rats. In other words, they displayed anti-inflammatory activity. On the other hand, hyperbaric oxygen treatment did not consistently modify the anti-inflammatory effect of diclofenac in this model. (C) 2001 Elsevier Science B.V. All rights reserved.