Linkage mapping of a novel susceptibility locus for Behcet's disease to chromosome 6p22-23

Gul A., Hajeer A., Worthington J., Ollier W., Silman A.

ARTHRITIS AND RHEUMATISM, cilt.44, sa.11, ss.2693-2696, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 11
  • Basım Tarihi: 2001
  • Dergi Adı: ARTHRITIS AND RHEUMATISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2693-2696
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective. The etiology of Behcet's disease is unknown; however, familial aggregation studies indicate a strong genetic background and a complex inheritance model. Association of HLA-B51 with Behcet's disease is regarded as being the strongest evidence of genetic contribution described to date. A low rate of recombination was observed within the telomeric end of the major histocompatibility complex up to the HFE gene, which causes hereditary hemochromatosis. We therefore hypothesized that the telomere of 6p may harbor a susceptibility gene for Behcet's disease.