A guide to acquired vitamin K coagulophathy diagnosis and treatment: the Russian perspective

WOJCIECHOWSKI V. V., CALINA D., TSAROUHAS K., PIVNIK A. V., SERGIEVICH A. A., KODINTSEV V. V., ...Daha Fazla

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.25, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 25
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1186/s40199-017-0175-z
  • Dergi Adı: DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Vitamin K, Acquired coagulopathy, Rodenticides, FRESH-FROZEN PLASMA, MUNCHAUSEN-SYNDROME, VENOUS THROMBOEMBOLISM, OVER-ANTICOAGULATION, INDUCED COAGULOPATHY, SUPERWARFARIN, BRODIFACOUM, RODENTICIDE, WARFARIN, HEMORRHAGE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Physicians often come across with cases of vitamin K antagonists-dependent coagulopathy for reasons such as accidental use of the vitamin K antagonists (VKA), excessive administration of prescribed anticoagulants of indirect action or not reported administration of vitamin K antagonists due to memory impairment and/or other mental disorders, even deliberate use thereof (attempt to murder or suicide). Rodenticide-poisoning (coumarins, warfarins) via food or occupational accidents are difficult to diagnose. This article discusses different types of acquired vitamin K-dependent coagulopathy. Differential diagnosis is primarily based on patient statements before additional causes of vitamin K deficiency are explored. Even when pathological vitamin K deficiency is not determined, appropriate and urgent medical treatment is necessary: administration of fresh frozen plasma or concentrated factors of the prothrombin complex, administration of vitamin K remedies along with symptomatic therapy. With early diagnosis and prescription of appropriate therapy, prognosis is favorable.