Cox-2 gene variants in migraine


Dasdemir S. , Çetinkaya Y., Gencer M. , Ozkok E. , Aydin M. , Cakmakoglu B.

GENE, vol.518, no.2, pp.292-295, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 518 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.1016/j.gene.2012.12.110
  • Journal Name: GENE
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.292-295
  • Keywords: Migraine, Cox-2, Polymorphism, CYCLOOXYGENASE-2, EXPRESSION, ASSOCIATION, POLYMORPHISMS, ROFECOXIB, INDUCTION, VITILIGO, RISK, PAIN

Abstract

Purpose: Migraine is a multifactorial and complex disorder, and any clear diagnostic marker to assess the status of the migraineurs has not been established, yet. Nonsteroidal anti-inflammatory drugs reduce production of prostanoids including PGE2 by inhibiting COX-1 and/or COX-2, and thereby suppress inflammatory pain in patients suffering from rheumatoid arthritis, osteoarthritis, and migraine. Thus, COX-2 regulation is important in the pathogenesis and treatment of migraine. We prospectively investigated COX-2-765G -> C and COX-2-1195A -> G gene polymorphisms which may account for an increased risk of migraine.