Effects of SR-BI rs5888 and rs4238001 variations on hypertension

Caykara B., Alsaadoni H., Pence H. H., Pence S., Aydogan H., Sabancelebi S., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.44, no.4, pp.549-553, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.1515/tjb-2018-0394
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.549-553
  • Keywords: Hypertension, SR-BI, rs5888, rs4238001, HIGH-DENSITY-LIPOPROTEIN, SCAVENGER RECEPTOR, GENE POLYMORPHISMS, I GENE, ASSOCIATION, CHOLESTEROL, CONSUMPTION, EXPRESSION, BINDING, PROTEIN
  • Istanbul University Affiliated: Yes

Abstract

Background: Scavenger receptor class B, type I (SR-BI), involved in reverse cholesterol pathway, is a multilipoprotein receptor and capable of binding HDL, LDL and VLDL. SR-BI may contribute to the development of hypertension due to accumulation of cholesterol in the vessel wall via transporting lipoproteins. Therefore, it was aimed to investigate the relationship between SR-BI rs5888 and rs4238001 variants in the patient with hypertension.