ADP-ribosylation of serum proteins: Elevated levels in neoplastic cases due to altered NAD/ADP-ribose metabolism


Albeniz I., Nurten R., Bermek E.

CANCER INVESTIGATION, cilt.15, ss.217-223, 1997 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 15 Konu: 3
  • Basım Tarihi: 1997
  • Doi Numarası: 10.3109/07357909709039718
  • Dergi Adı: CANCER INVESTIGATION
  • Sayfa Sayıları: ss.217-223

Özet

ADP-ribosylation of human serum proteins was studied in various groups of disorders. In most of these groups, the extent of ADP-ribosylation did not show a divergence from the group of normal controls. Neoplastic diseases revealed, however, a unique group, with more than fivefold increases in ADP-ribosylation levels over the other groups. Blood samples with high levels of ADP-ribosylation revealed, in general, increased serum NAD glycohydrolase activities and low levels of serum NAD.