Perampanel in Parkinson Disease Fluctuations: A Double-Blind Randomized Trial With Placebo and Entacapone

Rascol O., Barone P., Behari M., Emre M. , Giladi N., Olanow C. W. , ...Daha Fazla

CLINICAL NEUROPHARMACOLOGY, cilt.35, ss.15-20, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 35 Konu: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1097/wnf.0b013e318241520b
  • Sayfa Sayıları: ss.15-20


Objectives: Perampanel is a selective and noncompetitive alpha-amino-3-hydroxy-5-methylisoxazole propionic acid-type glutamate receptor antagonist that improves motor symptoms in animal models of Parkinson disease (PD). The aim of this study was to assess the efficacy and tolerability of perampanel in L-dopa-treated patients with moderately severe PD and motor fluctuations using an active comparator study design.