Enhancement of immune response of HBsAg loaded poly (L-lactic acid) microspheres against Hepatitis B through incorporation of alum and chitosan

Pandit, Sreenivas; Cevher, Erdal; Zariwala, Mohammed; Somavarapu, Satyanarayana; Alpar, H.

doi:10.1080/02652040701443700

Enhancement of immune response of HBsAg loaded poly (L-lactic acid) microspheres against Hepatitis B through incorporation of alum and chitosan

Pandit S., Cevher E., Zariwala M. G., Somavarapu S., Alpar H. O.

JOURNAL OF MICROENCAPSULATION, cilt.24, sa.6, ss.539-552, 2007 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 24 Sayı: 6
Basım Tarihi: 2007
Doi Numarası: 10.1080/02652040701443700
Dergi Adı: JOURNAL OF MICROENCAPSULATION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.539-552
Anahtar Kelimeler: Hepatitis B surface antigen, vaccine, microsphere, poly (L-lactic acid), chitosan, alum, cytokine, SINGLE-SHOT, BIODEGRADABLE MICROPARTICLES, IMMUNOLOGICAL EVALUATION, PLGA MICROSPHERES, VACCINE, IMMUNIZATION, DELIVERY, PROTEIN, PARTICLES, RELEASE
İstanbul Üniversitesi Adresli: Evet

Özet

Purpose: Poly (L-lactic acid) (PLA) microparticles encapsulating Hepatitis B surface antigen (HBsAg) with alum and chitosan were investigated for their potential as a vaccine delivery system.