Lifelong consumption of sodium selenite: Gender differences on blood-brain barrier permeability in convulsive, hypoglycemic rats
BIOLOGICAL TRACE ELEMENT RESEARCH, vol.124, no.1, pp.12-19, 2008 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 124 Issue: 1
- Publication Date: 2008
- Doi Number: 10.1007/s12011-008-8101-3
- Journal Name: BIOLOGICAL TRACE ELEMENT RESEARCH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.12-19
- Istanbul University Affiliated: Yes
Abstract
The aim of this study was to compare the effects of hypoglycemia and induced convulsions on the blood-brain barrier permeability in rats with or without lifelong administration of sodium selenite. There is a significant decrease of the blood-brain barrier permeability in three brain regions of convulsive, hypoglycemic male rats treated with sodium selenite when compared to sex-matched untreated rats (p < 0.05), but the decrease was not significant in female rats (p > 0.05). The blood-brain barrier permeability of the left and right hemispheres of untreated, moderately hypoglycemic convulsive rats of both genders was better than their untreated counterparts (p < 0.05). Our results suggest that moderate hypoglycemia and lifelong treatment with sodium selenite have a protective effect against blood-brain barrier permeability during convulsions and that the effects of sodium selenite are gender-dependent.