Lifelong consumption of sodium selenite: Gender differences on blood-brain barrier permeability in convulsive, hypoglycemic rats

Seker F. B. , Akgul S., Oztas B.

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.124, sa.1, ss.12-19, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 124 Konu: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s12011-008-8101-3
  • Sayfa Sayıları: ss.12-19


The aim of this study was to compare the effects of hypoglycemia and induced convulsions on the blood-brain barrier permeability in rats with or without lifelong administration of sodium selenite. There is a significant decrease of the blood-brain barrier permeability in three brain regions of convulsive, hypoglycemic male rats treated with sodium selenite when compared to sex-matched untreated rats (p < 0.05), but the decrease was not significant in female rats (p > 0.05). The blood-brain barrier permeability of the left and right hemispheres of untreated, moderately hypoglycemic convulsive rats of both genders was better than their untreated counterparts (p < 0.05). Our results suggest that moderate hypoglycemia and lifelong treatment with sodium selenite have a protective effect against blood-brain barrier permeability during convulsions and that the effects of sodium selenite are gender-dependent.