Some 3-hydrazono-2-indolinones and N-Mannich bases as potential anticonvulsants
FARMACO, cilt.51, sa.6, ss.437-442, 1996 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 6
- Basım Tarihi: 1996
- Dergi Adı: FARMACO
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, International Pharmaceutical Abstracts
- Sayfa Sayıları: ss.437-442
- İstanbul Üniversitesi Adresli: Evet
Özet
In this study a new series of 3-aryloxy/arylthioxyacetylhydrazono-2-indolinones obtained by condensation,of isatin with aryoxy/arythioxyacetylhydrazines were treated with morpholine and formaldehyde to yield 1-morpholinomethyl-3-aryloxy/arylthioxyacetylhydrazone-2-indolinones. Structures of all the compounds were assigned on the basis of spectral data (UV, IR, H-1-NMR, EIMS) and elemental analyses. Anticonvulsant evaluation of the compounds revealed varying degrees of activity against. pentylenentetrazole induced seizures.