Comparative study on the effect of aspirin, TP receptor antagonist and TxA(2) synthase inhibitor on the vascular tone of human saphenous vein and internal mammary artery.

Ozen, Gülsev; Aljesri, Khadija; Abdelazeem, Heba; Norel, Xavier; Turkyılmaz, Gulsum; Turkyılmaz, Saygın; Topal, Gokce

doi:10.1016/j.lfs.2021.120073

Comparative study on the effect of aspirin, TP receptor antagonist and TxA(2) synthase inhibitor on the vascular tone of human saphenous vein and internal mammary artery.

Ozen G., Aljesri K., Abdelazeem H., Norel X., Turkyılmaz G., Turkyılmaz S., ...More

Life sciences, vol.286, pp.120073, 2021 (SCI-Expanded)

Publication Type: Article / Article
Volume: 286
Publication Date: 2021
Doi Number: 10.1016/j.lfs.2021.120073
Journal Name: Life sciences
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
Page Numbers: pp.120073
Keywords: TxA(2), Aspirin, TP receptor antagonist, TxS inhibitor, Saphenous vein, Internal mammary artery, Vascular tone, PROSTAGLANDIN E-2, INDUCED CONTRACTION, THROMBOXANE, REACTIVITY, LATANOPROST, U46619
Istanbul University Affiliated: Yes

Abstract

Aims: Thromboxane (TxA(2)) is synthesized from arachidonic acid (AA) via thromboxane synthase (TxS) enzyme and induces vasoconstriction via TP receptor. Our aim is to compare the effects of aspirin, TxS inhibitor and TP receptor antagonist on vascular reactivity of bypass grafts (saphenous vein and internal mammary artery).